Depura is in Barmer District of Rajasthan, close to Kalanpur which lies 7 km away in the northern direction. Surpura lies to the north-east at a distance of 9 km. Some of the other nearby towns include Doli, 12 km to the north; Pipli, 14 km to the east and Majal, 18 km to the south.
Samdhari Junction Railway Station and Jodhpur Airport provide convenient access.