Managed by the South Central Railways, Santamagulur Railway Station lies on the Narasaraopet-Donakonda rail route. Guntur-Guntakal Passenger, Donakonda-Guntur Passenger, Guntur-Hubli Passenger, Guntur-Kacheguda Passenger and Tenali-Donakonda Passenger are the main trains that pass through this station.