Of the two railway stations in Nellore, Nellore South Railway Station falls on the Nellore-Gudur rail route. Bitragunta-Chennai Central Passenger, Tirupati-Ongole Passenger and Vijayawada-Gudur Passenger are the main train connections.
Managed by the South Central Railways, the station is located about 2 km from Nellore Railway Station. Vedayapalem Railway Station is 5 km to the south of Nellore South Railway Station.