Khamgaon is a taluk headquarters town in Buldhana District, located on National Highway 6. Located to the north-east of Buldhana, Khamgaon is 15 km south of Jalam and 16 km south-west of Shegaon. Madakhed is 20 km north-west.
Khamgaon is a prominent center of cotton trade. Gajanan Maharaja Temple in Shegaon is an interesting tourist destination nearby.