Thamballapalle is a taluk headquarters in Chittoor District in Andhra Pradesh. It is located on the eastern banks of the Papagni River and is about 70 km north-west of Chittoor.
Thamballapalle is served by Bangalore International Airport. Mulacalacheruvu Railway Station, on the Vayalpad-Guntakal rail route, is the convenient railhead.